Detalhe da pesquisa
1.
NLRP12 senses heme and PAMPs to drive necrotic cell death and inflammation.
Mol Cell
; 83(15): 2621-2623, 2023 08 03.
Artigo
Inglês
| MEDLINE | ID: mdl-37541218
2.
Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions.
Nat Immunol
; 17(12): 1361-1372, 2016 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-27798618
3.
The complement alternative pathway in paroxysmal nocturnal hemoglobinuria: From a pathogenic mechanism to a therapeutic target.
Immunol Rev
; 313(1): 262-278, 2023 01.
Artigo
Inglês
| MEDLINE | ID: mdl-36110036
4.
Safety, tolerability, and activity of the active C1s antibody riliprubart in cold agglutinin disease: a phase 1b study.
Blood
; 143(8): 713-720, 2024 Feb 22.
Artigo
Inglês
| MEDLINE | ID: mdl-38085846
5.
Regulation of kynurenine metabolism by blood donor genetics and biology impacts red cell hemolysis in vitro and in vivo.
Blood
; 143(5): 456-472, 2024 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37976448
6.
Treatment outcomes of complement protein C5 inhibition in 509 UK patients with paroxysmal nocturnal hemoglobinuria.
Blood
; 143(12): 1157-1166, 2024 Mar 21.
Artigo
Inglês
| MEDLINE | ID: mdl-38142401
7.
Hemolysis-driven IFNα production impairs erythropoiesis by negatively regulating EPO signaling in sickle cell disease.
Blood
; 143(11): 1018-1031, 2024 Mar 14.
Artigo
Inglês
| MEDLINE | ID: mdl-38127913
8.
Discovering C3 targeting therapies for paroxysmal nocturnal hemoglobinuria: Achievements and pitfalls.
Semin Immunol
; 59: 101618, 2022 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35764467
9.
Analysis of MRI-derived spleen iron in the UK Biobank identifies genetic variation linked to iron homeostasis and hemolysis.
Am J Hum Genet
; 109(6): 1092-1104, 2022 06 02.
Artigo
Inglês
| MEDLINE | ID: mdl-35568031
10.
Mitapivat versus Placebo for Pyruvate Kinase Deficiency.
N Engl J Med
; 386(15): 1432-1442, 2022 04 14.
Artigo
Inglês
| MEDLINE | ID: mdl-35417638
11.
Rare germline complement factor H variants in patients with paroxysmal nocturnal hemoglobinuria.
Blood
; 141(15): 1812-1816, 2023 04 13.
Artigo
Inglês
| MEDLINE | ID: mdl-36626252
12.
Dietary iron restriction protects against vaso-occlusion and organ damage in murine sickle cell disease.
Blood
; 141(2): 194-199, 2023 01 12.
Artigo
Inglês
| MEDLINE | ID: mdl-36315910
13.
Fatigue of red blood cells under periodic squeezes in ECMO.
Proc Natl Acad Sci U S A
; 119(49): e2210819119, 2022 12 06.
Artigo
Inglês
| MEDLINE | ID: mdl-36454755
14.
Endothelial VWF is critical for the pathogenesis of vaso-occlusive episode in a mouse model of sickle cell disease.
Proc Natl Acad Sci U S A
; 119(34): e2207592119, 2022 08 23.
Artigo
Inglês
| MEDLINE | ID: mdl-35969769
15.
The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages.
Proc Natl Acad Sci U S A
; 119(35): e2121251119, 2022 08 30.
Artigo
Inglês
| MEDLINE | ID: mdl-35994670
16.
A rationally engineered small antimicrobial peptide with potent antibacterial activity.
J Cell Biochem
; 125(2): e30503, 2024 02.
Artigo
Inglês
| MEDLINE | ID: mdl-37992185
17.
Sutimlimab in Cold Agglutinin Disease.
N Engl J Med
; 384(14): 1323-1334, 2021 04 08.
Artigo
Inglês
| MEDLINE | ID: mdl-33826820
18.
Red blood cell-derived arginase release in hemolytic uremic syndrome.
J Transl Med
; 22(1): 17, 2024 Jan 04.
Artigo
Inglês
| MEDLINE | ID: mdl-38178089
19.
Engineering Therapeutics to Detoxify Hemoglobin, Heme, and Iron.
Annu Rev Biomed Eng
; 25: 1-21, 2023 06 08.
Artigo
Inglês
| MEDLINE | ID: mdl-37289555
20.
Hemolysis, free hemoglobin toxicity, and scavenger protein therapeutics.
Blood
; 140(17): 1837-1844, 2022 10 27.
Artigo
Inglês
| MEDLINE | ID: mdl-35660854